Regeneration / Octapeptide
SNAP-8
An acetylated octapeptide examined for its interaction with the SNARE complex.
- Research domain
- Regeneration
- Presentation
- 10 mg / vial
- Assayed purity
- ≥ 99% by HPLC
- Evidence base
- Emerging
Also designatedAcetyl octapeptide-3 · Acetyl glutamyl heptapeptide-3 · Acetyl octapeptide-1
Quick facts
- Purity specification
- ≥ 99% by HPLC
- Physical form
- Lyophilised powder
- Presentation
- 10 mg / vial
- Evidence base
- Emerging
- Intended use
- Laboratory research only
Research overview
How it is characterised
SNAP-8 is a synthetic acetylated octapeptide extending the sequence of the SNAP-25 protein N-terminus. The published record examines it as a competitive analogue within the soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex — the SNARE assembly that mediates vesicle docking — and characterises its behaviour in dermal and neuromuscular junction models.
Mechanism
Described as competing with SNAP-25 for a position in the SNARE complex, so that the assembly forms less efficiently. The literature examines the consequence for vesicle docking and catecholamine release in cell models, and the acetylation at the N-terminus is studied for the stability it confers on a short sequence.
Applications
- Exocytosis pathway research
- Dermal model characterisation
- Peptide analogue competition assays
- Comparative short-peptide stability studies
Research focus
Areas of published investigation
The following describe where this compound has been examined in the scientific literature. They are not claims of effect, and nothing here should be read as a therapeutic indication.
- 01SNARE complex assembly
- 02Vesicle docking and exocytosis
- 03Competitive peptide analogue behaviour
- 04Dermal matrix and expression models
Research compatibility
Frequently co-studied
Compounds that appear alongside SNAP-8 in the published record, and the reason the literature examines them together.
Molecular & pharmacokinetic data
The physical record
Verify every figure against the certificate of analysis for the batch you hold. Where the label and the assay disagree, the assay is the number to calculate from.
- CAS number
- 868844-74-0
- Molecular formula
- C₄₀H₆₈N₁₄O₁₆
- Molar mass
- ≈ 1025.06 g/mol
- Sequence
- Ac-EEMQRRAD-NH₂
- Reported half-life
- Not established in circulation; examined topically
- Solubility
- Readily soluble in water
Storage
Store lyophilised at −20 °C, protected from light and moisture. Following reconstitution, hold at 2–8 °C and use within the interval stated on the batch certificate of analysis.
Handling
Allow the vial to reach ambient temperature before breaking the seal so atmospheric moisture does not condense onto the cake. Introduce diluent slowly against the vial wall rather than directly onto the powder, and swirl rather than shake. Avoid repeated freeze-thaw cycles; aliquot where a preparation will be drawn on more than once.
Packaging
Amber borosilicate vial with butyl stopper and aluminium crimp seal, presented in a matte debossed box with die-cut foam insert and magnetic closure.
Selected references
The published record
A starting point rather than a survey. Entries are listed for orientation and do not constitute endorsement of any interpretation drawn from them.
- 01SNARE complex assembly and vesicle fusionNature Structural & Molecular Biology, 2008
- 02Peptide analogues of SNAP-25 in cell modelsInternational Journal of Cosmetic Science, 2013
- 03Short acetylated peptides and enzymatic stabilityJournal of Peptide Science, 2017
This catalogue is presented for informational purposes only. It is not an offer of sale, and it makes no medical or therapeutic claim.
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Enquiries
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