Neuro / Heptapeptide
Selank
A synthetic heptapeptide derived from tuftsin, studied for neuropeptide signalling.
- Research domain
- Neuro
- Presentation
- 10 mg / vial
- Assayed purity
- 99.74%
- Evidence base
- Emerging
Also designatedTuftsin analogue · TP-7 · Selank acetate
Quick facts
- Purity specification
- ≥ 99% by HPLC
- Physical form
- Lyophilised powder
- Presentation
- 10 mg / vial
- Evidence base
- Emerging
- Intended use
- Laboratory research only
Current batch · EVN-SEL-2604
Meridian Analytical Laboratories, 15 Apr 2026. Assayed content 10.03 mg / 10 mg.
View certificateResearch overview
How it is characterised
Selank is a synthetic heptapeptide constructed from the immunomodulatory tetrapeptide tuftsin extended by a proline-glycine-proline stabilising sequence. Literature examines its influence on brain-derived neurotrophic factor expression, monoaminergic turnover and enkephalin degradation kinetics in preclinical central nervous system models.
Mechanism
The proline-glycine-proline extension is described as conferring resistance to peptidase cleavage, extending the window over which the tuftsin core is available. Published work examines inhibition of enkephalin-degrading enzymes and changes in GABAergic and serotonergic gene expression in hippocampal preparations.
Applications
- Neuropeptide research
- Central nervous system model studies
- Neurotrophic factor assays
- Comparative regulatory peptide investigation
Research focus
Areas of published investigation
The following describe where this compound has been examined in the scientific literature. They are not claims of effect, and nothing here should be read as a therapeutic indication.
- 01BDNF expression modulation
- 02Monoaminergic turnover
- 03Enkephalin degradation kinetics
- 04GABAergic pathway characterisation
Research compatibility
Frequently co-studied
Compounds that appear alongside Selank in the published record, and the reason the literature examines them together.
Molecular & pharmacokinetic data
The physical record
Verify every figure against the certificate of analysis for the batch you hold. Where the label and the assay disagree, the assay is the number to calculate from.
- CAS number
- 129954-34-3
- Molecular formula
- C₃₃H₅₇N₁₁O₉
- Molar mass
- ≈ 751.88 g/mol
- Sequence
- TKPRPGP
- Reported half-life
- Extended relative to unmodified tuftsin
- Solubility
- Readily soluble in water
Analytical record
Batch EVN-SEL-2604
Analysed by Meridian Analytical Laboratories, ISO/IEC 17025 accredited, under accession MAL-26-04322. The certificate is retrievable from the issuing laboratory independently of us.
Full certificate- Purity
- 99.74%RP-HPLC, UV 214 nm · spec ≥ 99.0%
- Identity
- 751.9 Da (theoretical 751.9)ESI-MS · spec Conforms to theoretical mass
- Assayed content
- 100.3% of labelRP-HPLC against reference standard · spec 95.0 – 110.0% of label
- Water content
- 2.6%Karl Fischer titration · spec ≤ 8.0%
- Residual solvents
- Acetonitrile 58 ppm; TFA below quantitationHeadspace GC-FID · spec Within USP <467> limits
- Appearance
- White lyophilised cakeVisual inspection · spec Conforms
Storage
Store lyophilised at −20 °C, protected from light and moisture. Following reconstitution, hold at 2–8 °C and use within the interval stated on the batch certificate of analysis.
Handling
Allow the vial to reach ambient temperature before breaking the seal so atmospheric moisture does not condense onto the cake. Introduce diluent slowly against the vial wall rather than directly onto the powder, and swirl rather than shake. Avoid repeated freeze-thaw cycles; aliquot where a preparation will be drawn on more than once.
Packaging
Amber borosilicate vial with butyl stopper and aluminium crimp seal, presented in a matte debossed box with die-cut foam insert and magnetic closure.
Selected references
The published record
A starting point rather than a survey. Entries are listed for orientation and do not constitute endorsement of any interpretation drawn from them.
- 01Selank and enkephalin degradation kineticsBulletin of Experimental Biology and Medicine, 2011
- 02Regulatory peptides and hippocampal gene expressionNeurochemical Research, 2015
- 03Tuftsin-derived peptides in the central nervous systemPeptides, 2019
This catalogue is presented for informational purposes only. It is not an offer of sale, and it makes no medical or therapeutic claim.
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Enquiries
Request the batch documentation.
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