Metabolism / Mitochondrial
MOTS-c
A mitochondrial-derived peptide studied for AMPK activation and metabolic homeostasis.
- Research domain
- Metabolism
- Presentation
- 10 mg / vial
- Assayed purity
- 99.29%
- Evidence base
- Established
Also designatedMitochondrial ORF of the 12S rRNA type-c · MOTSc · Mitochondrial-derived peptide
Quick facts
- Purity specification
- ≥ 99% by HPLC
- Physical form
- Lyophilised powder
- Presentation
- 10 mg / vial
- Evidence base
- Established
- Intended use
- Laboratory research only
Current batch · EVN-MOTS-2604
Northgate Bioanalytical, 21 Apr 2026. Assayed content 9.94 mg / 10 mg.
View certificateResearch overview
How it is characterised
MOTS-c is a sixteen amino acid peptide encoded within the mitochondrial 12S ribosomal RNA gene, one of a small class of mitochondrial-derived peptides. Published work examines its translocation to the nucleus under metabolic stress and its characterised action on the AMP-activated protein kinase pathway and folate-methionine cycle intermediates.
Mechanism
Described as inhibiting the folate cycle and accumulating AICAR, which in turn activates AMPK. Under metabolic stress the peptide is reported to translocate to the nucleus and associate with stress-response transcription factors, positioning it as a signal between the mitochondrial and nuclear genomes.
Applications
- Mitochondrial biology research
- Metabolic homeostasis characterisation
- Exercise physiology model studies
- Cellular energy sensing assays
Research focus
Areas of published investigation
The following describe where this compound has been examined in the scientific literature. They are not claims of effect, and nothing here should be read as a therapeutic indication.
- 01AMPK pathway activation
- 02Mitochondrial-nuclear signalling
- 03Folate-methionine cycle intermediates
- 04Glucose utilisation in skeletal muscle models
Research compatibility
Frequently co-studied
Compounds that appear alongside MOTS-c in the published record, and the reason the literature examines them together.
- NAD+The standard longevity pairing — energy sensing examined alongside redox cofactor availability.
- RetatrutideCombined where incretin signalling and cellular energy sensing are measured together.
- BPC-157 + TB-500Co-studied in models where mitochondrial function accompanies tissue repair.
Included in research stacks
Molecular & pharmacokinetic data
The physical record
Verify every figure against the certificate of analysis for the batch you hold. Where the label and the assay disagree, the assay is the number to calculate from.
- CAS number
- 1627580-64-6
- Molecular formula
- C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molar mass
- ≈ 2174.62 g/mol
- Sequence
- MRWQEMGYIFYPRKLR
- Reported half-life
- Short; rapid clearance reported
- Solubility
- Soluble in bacteriostatic water
Analytical record
Batch EVN-MOTS-2604
Analysed by Northgate Bioanalytical, ISO/IEC 17025 accredited, under accession NGB-26-0431. The certificate is retrievable from the issuing laboratory independently of us.
Full certificate- Purity
- 99.29%RP-HPLC, UV 214 nm · spec ≥ 99.0%
- Identity
- 2174.8 Da (theoretical 2174.6)ESI-MS · spec Conforms to theoretical mass
- Assayed content
- 99.4% of labelRP-HPLC against reference standard · spec 95.0 – 110.0% of label
- Water content
- 4.8%Karl Fischer titration · spec ≤ 8.0%
- Residual solvents
- Acetonitrile 126 ppm; TFA 72 ppmHeadspace GC-FID · spec Within USP <467> limits
- Appearance
- White lyophilised cakeVisual inspection · spec Conforms
Storage
Store lyophilised at −20 °C, protected from light and moisture. Following reconstitution, hold at 2–8 °C and use within the interval stated on the batch certificate of analysis.
Handling
Allow the vial to reach ambient temperature before breaking the seal so atmospheric moisture does not condense onto the cake. Introduce diluent slowly against the vial wall rather than directly onto the powder, and swirl rather than shake. Avoid repeated freeze-thaw cycles; aliquot where a preparation will be drawn on more than once.
Packaging
Amber borosilicate vial with butyl stopper and aluminium crimp seal, presented in a matte debossed box with die-cut foam insert and magnetic closure.
Selected references
The published record
A starting point rather than a survey. Entries are listed for orientation and do not constitute endorsement of any interpretation drawn from them.
- 01The mitochondrial-derived peptide MOTS-cCell Metabolism, 2015
- 02MOTS-c nuclear translocation under metabolic stressCell Metabolism, 2018
- 03Mitochondrial-derived peptides as signalling moleculesTrends in Endocrinology & Metabolism, 2021
This catalogue is presented for informational purposes only. It is not an offer of sale, and it makes no medical or therapeutic claim.
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Enquiries
Request the batch documentation.
Ask a specialist about MOTS-c — its current batch, analytical documentation, and what can be supplied to your territory.